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The SAGE Handbook of Drug & Alcohol Studies

The SAGE Handbook of Drug & Alcohol Studies
Biological Approaches

Edited by:

October 2016 | 578 pages | SAGE Publications Ltd

With contributions from leading international academics across the biological sciences, this handbook takes a critical look at the key contemporary issues and debates in the field. The 31 chapters are divided into four parts:

Part I Determination of Substance Misuse

Part II PK and PD in Relation to Patterns of Use   

Part III Detection and Treatment of Drug and Alcohol Use

Part IV Controversies and New Approaches

This Handbook is an excellent reference text for the growing number of academics, students, scientists and practitioners in the drug and alcohol studies community, and will be a vital resource to the allied professions involved in work-place drug testing, clinical toxicology, and forensic science.

Part I: Determination of Substance Misuse
Rohit Jaibhagwan Lodhi, David Rossolatos and Katherine Jean Aitchison
1. Genetics and genomics in addiction research
Kim Wolff
2. Basic Pharmacokinetics of Substance Misuse
Jason White & Andrew A. Somogyi
3. Future Directions: The role of pharmacogenomics
Part II: PK and PD in Relation to Patterns of Use
Matthew Goldin and E. Jane Marshall
4. Alcohol: Pharmacokinetics and Pharmacodynamics
Noorzurani Robson
5. Nicotine: The Pharmacokinetics of Nicotine and Cotinine
Verena Metz & Sandy Corner
6. Opioids: A Discussion of Pharmacokinetics and Pharmacodynamics in Those Who Misuse Drugs
Glenn Dumont
7. Cocaine: pharmacokinetics, pharmacodynamics and addictive potential
Kim P.C. Kuypers, Eef Theunissen and Jan Ramaekers
8. Amphetamine & Methamphetamine: Pharmacokinetics and Pharmacodynamics
Magí Farré, Esther Papaseit & Rafael de la Torre
9. MDMA: Pharmacokinetics
Alyson Bond & Malcolm Lader
10. Benzodiazepines: A discussion of pharmacokinetic and pharmacodynamic effects in those who misuse the drug
Kim Wolff
11. Ketamine: the pharmacokinetics and pharmacodynamics in medicinal and misusing populations
Dave Allsop, Richard Kevin & Jonathon Arnold
12. Cannabis: The pharmacokinetics and pharmacodynamics of recreational and medicinal cannabis
Deepak D'Souza & Aarti Gupta
13. Synthetic cannabinoids: The pharmacokinetics and pharmacodynamics of ‘Spice’ and other synthetic cannabinoids
Lorenza Colzato & Manuel Ruiz
14. Khat, Methedrone and MDPV: A discussion of pharmacokinetic and pharmacodynamic parameters
John B. Saunders, Jason Connor & Gerald Feeney
15. Gamma-hydroxybutyric Acid (GHB): A discussion of pharmacokinetic and pharmacodynamic effects of GHB including its analogues
Jason Connor, John Saunders, Adrian Kelly, Gerald Feeney
16. Polysubstance Use
Part III: Detection and Treatment of Drug and Alcohol Use
Kim Wolff & Michael Gossop
17. A brief overview of the detection of drug and alcohol use: the matching of purposes and procedures.
Natalie E Walsham & Roy A Sherwood
18. Biomarkers of alcohol misuse
Kim Wolff, Steven Karch, Jason White
19. Treatment of Opioid Dependence
Bram Miserez & Alexander van Nujs
20. Wastewater Analysis for the Measurement of Population Level Drug Use: Sewage-Based Epidemiology
Part IV: Special Settings
A Robert Forrest
21. Forensic toxicology and death investigation
Kim Wolff, Samantha Gross, Noor Zurani-Robson and Jane Marshall
22. Alcohol-related offences, alcohol use disorders and the workplace
Steven B Karch
23. Future directions: What is the way forward for toxicology and forensic research?
Part V: Controversies and New Approaches
Bjarni O. Rafnar and Gudrun Dora Bjarnadottir
24. Intravenous abuse of methylphenidate
Christian P. Müller
25. Non addictive drug use: The way forward
Kim Wolff
26. Different Approaches to setting limits for drugs and alcohol use when driving
Mark D. Griffiths, Daria J. Kuss, Halley M. Pontes and Joël Billieux
27. Where do gambling and internet ‘addictions’ belong? The status of ‘other’ addictions
Annie Crookes
28. Emerging Tobacco Trends from the Arabian Cultures (Waterpipe and Dokha): Global Prevalence, Health Risks and Propensity for Abuse
Deborah Zador
29 Treating Benzodiazepine Dependence - abstinence or maintenance?
Pieter-Jan Carpentier, Philip Asherson & Ulrich Muller
30. ADHD: pathways into addiction, diagnosis and pharmacotherapy
Susan Young and Ottilie Sedgwick
31. Exploratory models to explain attention deficit hyperactivity disorder and its association with substance use

This new volume provides a very welcome and much needed compilation of key articles and reviews on various aspects of drug abuse. It includes a very useful introductory section outlining the basic principles in pharmacokinetics and pharmacogenomics and the subsequent chapters delve further into these principles for various classes of drugs of abuse. The information is clearly laid out and is complemented with a section on detection and treatment of drug and alcohol abuse. Recent controversies and debates on key aspects of drug abuse this handbook will stimulate the reader into considering further innovative aspects in this field.  This handbook will prove to be a very reference textbook for toxicology students and a key addition to medical and health care science libraries.  

Janet Mifsud
Professor of Clinical Pharmacology, University of Malta

At times of crisis, we observe an increase in the severity of drugs and alcohol related problems and a rise in gambling and internet addiction. The SAGE Handbook of Drug & Alcohol Studies Volume 2 comes at the right time to deepen our understanding of addiction aetiology and new forms that affect every area of personal and family life. The Handbook raises awareness of treatment options for successful recovery and for fighting stigma in today’s turbulent environment. This Handbook is a valuable tool for academics, researchers, students and professionals who strive to transform evidence based knowledge into successful practice. 

Anna Tsiboukli
Head of KETHEA Department of Education, Hellenic Open University, Greece

Sample Materials & Chapters

Chapter 1

Kim Wolff

Kim Wolff is Professor of Addiction Science, at King's College London and has worked in the Addiction field for the last 25 years. Her PhD thesis investigated the pharmacokinetics of methadone in heroin dependent drug addicts at the Research School of Medicine, University of Leeds. Professor Wolff's main research interest is concerned with biomarkers of substance misuse and she has acted as an expert advisor to the UK Government National Treatment Agency for Substance Misuse (NTA); the National Collaborating Centre for Mental Health (NCCMH) and the National Institute for Clinical Excellence (NICE) in this regard. Her work has led to... More About Author

Jason White

Jason White is Professor of Pharmacology and Head, School of Pharmacy and Medical Sciences, University of South Australia. He has published extensively in the pharmacology of addictive drugs, particularly opioids and stimulants, and in the treatment of drug and alcohol dependence. He has experience in the management of alcohol and drug problems and in the provision of expert evidence related to drug effects in civil and criminal matters. He is currently Co-Chair of the WHO Expert Committee on Drug Dependence.  More About Author

Steven Karch

Steven Karch received his undergraduate degree from brown University, in Providence, Rhode Island, in the US. He attended graduate school in anatomy and cell biology at Stanford. He received his MD from Tulane University in New Orleans, did postgraduate training in Neuropathology at the Royal London Hospital and in Cardiac Pathology, also at Stanford University. Dr Karch is a Fellow of the Faculty of Forensic and Legal Medicine of the Royal College of Physicians London. He served as a cardiac pathologist at the office of the San Francisco Medical Examiner, publishing a number of books and papers when he worked there. Dr Karch is the... More About Author

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