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The Advanced Handbook of Methods in Evidence Based Healthcare
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The Advanced Handbook of Methods in Evidence Based Healthcare

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544 pages | SAGE Publications Ltd
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'This handbook is an excellent reflection of the growing maturity and methodological sophistication of the field of Health Technology Assessment. The Handbook covers a spectrum of issues, from primary evidence (clinical trials) through reviews and meta-analysis, to identifying and filling gaps in the evidence. Up-to-date, clearly written, and well-edited, the handbook is a needed addition to any personal or professional library dealing with Health Technology Assessment.'

Professor David Banta, TNO Prevention and Health, The Netherlands

'This text presents the most advanced knowledge on methodology in health care research, and will form the backbone of many future studies' - Paula Roberts, Nurse Researcher

The `effectiveness revolution' both in research and clinical practice, has tested available methods for health services research to the extreme. How far can observational methods, routine data and qualitative methods be used in health care evaluation? What cost and outcome measures are appropriate, and how should data be gathered?

With the support of over two million pounds from the British Health Technology Assessment Research Programme, the research project for this Handbook has led to both a synthesis of all of the existing knowledge in these areas and an agenda for future debate and research.

The chapters and their authors have been selected through a careful process of peer review and provide a coherent and complete approach to the field. The handbook has been a unique collaboration between internationally regarded clinicians, statisticians, epidemiologists, social scientists, health economists and ethicists. It provides the most advanced thinking and the most authoritative resource for a state of the art review of methods of evaluating health care and will be required reading for anyone involved in health services research and management.

 
Introduction
 
Methods in Evidence Based Healthcare and Health Technology Assessment - An Overview
 
PART ONE: CLINICAL TRIALS
Richard J Lilford and Andrew Stevens
Introduction
Richard J Lilford, Sarah Edwards, David Braunholtz, Jennifer Jackson, Jim Thornton and Jenny Hewison
Ethical Issues in the Design and Conduct of Randomized Controlled Trials
Richard E Ashcroft
Ethics of Clinical Trials
Social, Cultural and Economic Factors

 
Sue Ross, Carl Counsell, William J Gillespie, Adrian Grant, Robin Prescrott, Ian Russell, Iain Colthart, Sandra Kiauka, Daphne Russell and Sue Shepard
Factors That Limit the Number, Progress and Quality of Randomized Controlled Trials
A Systematic Review

 
Dianne O'Connell, Paul P Glasziou, Suzanne Hill, Jasminka Sarunac, Julia Lowe and David Henry
Results of Clinical Trials and Systematic Reviews
To Whom Do They Apply?

 
Rosemary Crow, Heather Gage, Sarah E Hampson, Jo Hart, Alan C Kimber and Hilary Thomas
The Placebo Effect
Methodological Process and Implications of a Structured Review

 
 
PART TWO: OBSERVATIONAL AND QUALITATIVE METHODS
Ray Fitzpatrick
Introduction
Colin Sanderson, Martin McKee, Annie Britton, Nicholas Black, Klim McPherson and Chris Bain
Randomized and Non-Randomized Studies
Threats to Internal and External Validity

 
Barnaby Reeves, Rachel MacLehose, Ian Harvey, Trevor Sheldon, Ian Russell and Andrew McLaren Spiers Black
A Review of Observational, Quasi-Experimental and Randomized Study Designs for the Evaluation of the Effectiveness of Healthcare Interventions
James Raftery, Andrew Stevens and Paul Roderick
The Potential Use of Routine Data Sets in Health Technology Assessment
James Lewsey, Gordon Murray, Alastair H Leyland and Andrew Boddy
Using Routine Data to Complement and Enhance the Results of Randomized Controlled Trials
Elizabeth Murphy and Robert Dingwall
Qualitative Methods in Health Technology Assessment
 
PART THREE: MEASUREMENT OF BENEFIT AND COST
John Brazier
Introduction
Ray Fitzpatrick, Claire Davey, Martin Buxton and David Jones
Criteria for Assessing Patient-Based Outcome Measures for Use in Clinical Trials
John Brazier, Mark Deverill and Colin Green
The Use of Health Status Measures in Economic Evaluation
Katharine Johnstone, Martin Buxton, David Jones and Ray Fitzpatrick
Collecting Resource Use Data for Costing in Clinical Trials
John Cairns and Marjon van der Pol
Eliciting Time Preferences for Health
Elaine McColl, Ann Jacoby, Lois Thomas, Jennifer Soutter, Claire Bamford, Nick Steen, Roger Thomas, Emma Harvey, Andrew Garratt and John Bond
The Conduct and Design of Questionnaire Surveys in Healthcare Research
 
PART FOUR: ANALYTICAL METHODS
Keith R Abrams
Introduction
David Spiegelhalter, Jonathan Myles, David Jones and Keith Abrams
Bayesian Methods
Martin Gulliford, Obioha C Ukoummunne, Susan Chinn, Jonathan Sterne, Peter Burney and Allan Donner
Methods for Evaluating Organization or Area-Based Health Interventions
Andrew Briggs and Alastair Gray
Handling Uncertainty in Economic Evaluation
Michael Campbell, Steven A Julious, Sarah Walker, Steve George and David Machin
A Review of the Use of the Main Quality of Life Measures, and Sample Size Determination for Quality of Life Measures, Particularly in Cancer Trials
Lucinda Billingham, Keith Abrams and David Jones
Simultaneous Assessment of Quality of Life and Survival Data
 
PART FIVE: CONSENSUS, REVIEWS AND META-ANALYSIS
Andrew Stevens and Keith R Abrams
Introduction
Fuijan Song, Alison Eastwood, Simon Gilbody, Lelia Buley and Alex Sutton
Publication and Related Biases
Alexander Sutton, David Jones, Keith Abrams, Trevor Sheldon and Fujian Song
Meta-Analysis in Health Technology Assessment
David Moher, Terry Klassen, Alison Jones Ba'Pham, Deborah Cook, Alejandro Jada, Peter Tugwell and Michael Moher
Assessing the Quality of Reports of Randomized Trials Included in Meta-Analyses
Attitudes, Practice, Evidence and Guides

 
Nick Black, Maggie Murphy, Donna Lamping, Martin McKee, Colin Sanderson, Janet Askham and Theresa Marteau
Consensus Development Methods, and Their Use in Creating Clinical Guidelines
 
PART SIX: IDENTIFYING AND FILLING GAPS IN THE EVIDENCE
Andrew Stevens
Introduction
Glenn Robert, Andrew Stevens and John Gabbay
Identifying New Health Care Technologies
Graham Mowatt, Adrian Grant, D Jane Bower, John A Brebner, John Cairns and Lorna McKee
Timing of Assessment of Fast-Changing Health Technologies
Gareth Harper, Joy Townsend and Martin Buxton
Preliminary Economic Evaluation of Health Technologies

Andrew J Stevens

Andrew Stevens is Professor of Public Health and former Head of Department and Division (of Primary Care, Public and Occupational Health). Andrew is interested in Health Services Research including health care needs assessment, health technology assessment and horizon scanning. He has edited the 4 volume Health Care Needs Assessment Series, and the Advanced Handbook of Methods in Evidence Based Healthcare. Andrew has had a close involvement with the National Institute for Health and Clinical Excellence (NICE) since its establishment in 2000, and has been Chairman of one of its Appraisal Committees for 6 years. More About Author

Keith R Abrams

Porf. Adrams' research includes: The development and application of Bayesian methods in healthcare evaluation, systematic reviews and meta-analysis and The joint modelling of longitudinal and time-to-event data. He has considerable experience of undertaking pradmatic TCT's and systematic reviews in a variety of settings, including cardiology, gastroenology, oncology and reproductive medicine. More About Author

John Brazier

John Brazier is Professor of Health Economics at the Health Economics and Decision Science section of the School of Health and Related Research at the University of Sheffield. He has more than 20 years’ experience of conducting economic evaluations of health care interventions for policy makers. He has also undertaken numerous economic evaluations alongside clinical trials and decision analytic models. He has a particular interest in the measurement and valuation of health for economic evaluation where he has published widely. He is perhaps best known for his work in developing a preference-based measure of health for the SF-36, but more... More About Author

Ray Fitzpatrick

Richard J Lilford

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